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Five of the 7 children had soft tissuelesions of the neck and back, suggestive of early fibrodysplasiaossificans progressiva flare-ups, 3 of whom had undergone invasivediagnostic procedures that exacerbated their condition. This is the first report of geneticconfirmation of fibrodysplasia ossificans progressiva beforethe appearance of heterotopic ossification. Pediatricians shouldbe aware of the early diagnostic features of [...]